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Graphical abstract Access this article Similar content being viewed by others Data availability The data that support the findings of this study are available from the corresponding author upon reasonable request

6 Previous studies have also found elevated circulating concentrations of erythritol precede coronary heart disease, 25,26 associated with diabetes, 27,28 obesity, 5 and arterial stiffness, 29 and may therefore be a marker of impaired metabolism

[DOI] [PubMed] [Google Scholar] 108.Dillard CJ, Litov RE, Savin WM, Dumelin EE, Tappel AL

Physiol Pharmacol 11(1):7 Gomathy G, Venkatesan D, Palani S (2015) Gastroprotective potentials of the ethanolic extract of Mukia maderaspatana against indomethacin-induced gastric ulcer in rats

In particular, the metabolism of dietary substrates such as choline and l-carnitine to trimethylamine (TMA) and subsequently to trimethylamine oxide (TMAO) by a hepatic enzyme flavin-containing monooxygenase 3 (FMO3) is of interest due to the strong associations of high circulating TMAO concentrations with the risk of numerous metabolic diseases and the risk of death from heart failure [4,5,6]