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In fact, high doses of stimulants (hello glutamate) can look just like schizophrenia: Consistent with the antipsychotic effects of depleting dopamine, high doses of stimulants induce a psychosis that clinically resembles the acute phase of paranoid schizophrenia All this speaks to excess glutamate

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A manual search of reference lists and database results was also performed to ensure completeness

Research and clinical experience suggest that IV NAD+ produces a sharp but short-lived spike in plasma levels that does not reliably translate to intracellular increases, which is where the therapeutic effect actually happens