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The requirement of a protein pre- or post-organ and -animal development is an important distinction that is not always considered in studies involving tissue-specific knockout mouse models but potentially requires additional investigation

The ability to regulate sensory input by filtering out irrelevant stimuli (to prevent sensory overflow) can also be enhanced by opioid agonists, as suggested by a study where a low dose of morphine (10 mg PO) in 18 males enhanced modulation of the startle reflex to a noise burst following a prestimulus, a phenomenon called prepulse inhibition (Quednow et al., 2008)

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While there were reported improvements in non-motor symptom scores for the 600 mg/day treatment group, no statistically significant changes in motor symptoms were observed when compared to placebo