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Since p53 plays various roles in radiation-induced injury, it is unclear which effect is dominant

Secondly, IGF-I has been proposed as an index of healthy aging, due to the finding that it directly correlates with the leukocyte telomere length[245, 246], a biomarker of human aging associated with increased risk of developing vascular diseases, metabolic disorders, and other age associated phenotypes[247, 248]

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And theres a concern among many clinicians that, because BPC-157 seems to influence growth-related pathways, theres a theoretical risk it could spur tumor growth if cancer cells are present