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EMT is a critical mechanism by which cancer cells detach from their primary location and establish new tumors in distant tissues, necessitating a phenotypic transformation that increases their motility and invasiveness

Tumor microenvironment as a therapeutic target in cancer

On the basis of optimum activation of glutathione peroxidase 4(GPX4), GSH is required to protect from ferroptosis [21]

doi: 10.1016/j.coi.2017.07.004 135 ZhangMWangYChenXZhangFChenJZhuHet al