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The essential role of LA in barrier function was determined in several animal experiments similar to those conducted by Burr and Burr (1, 2)

When a cell has higher levels of GSSG, then it can be implied that more oxidative stress has occurred within the cell

A.VodovotzY.GrishamM

Therefore, the most important function of GPX1-4 is to prevent oxidative stress by catalyzing the reduction of H 2 O 2 or organic hydroperoxides

35 As discussed earlier, trauma, coupled with an associated genotype, can damage keratinocytes, leading to the expression of IFN and TNF, activation of dendritic cells, and production of IL-23