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Observational trials are exploring many aspects of the disease, including speech difficulties in people with PD, the ways in which the disease affects sleep patterns, and the genetics of PD, as mutations in three known genes called SNCA , UCHL1 , and LRRK2 have been linked to the disease

A long-term follow up focussing on the alterations in gut microbiota and metabolic fluctuations could help us understand the pathogenesis better

However, no significant melanin index reduction was detected compared with baseline

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and Palmeri, V., 2020