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The glutaminase II pathway also plays important roles in providing anaplerotic carbon to the TCA cycle, supplying citrate carbon in prostate cancers, and closing the methionine salvage pathway (125)

These findings suggest that the cGAS-STING-LCN2 axis contributes to age-associated neurodegeneration (Jiang et al., 2023)

(2023) indicated that this interaction enhances macrophage phagocytic activity and NK cell cytotoxicity, thereby bolstering the hosts first line of defense against viral and bacterial infections (238)

Rasburicase is contraindicated in G6PD-deficient patients to prevent hemolysis and methemoglobinemia

Echinocandins are largely ineffective against Cryptococcus , and the efficacy of other agents is often compromised by host toxicity or fungal resistance (Denning, 2003) ( Supplementary File 1 )