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If a patient cannot maintain regular bowel movements, binder therapy must be paused or adjusted, as adding binders to a sluggish gut will only exacerbate systemic toxicity and inflammation

J Am Chem Soc 123:839850

Furthermore, the redox activity of PDI, but not its chaperone function, rescued motor dysfunction and axonopathy in zebrafish models of ALS expressing mutant SOD1, together implying that PDI has an important role both in vitro and in vivo (Parakh et al., 2020)

Animal models and experimental protocols All animal procedures were approved by the Institutional Animal Care and Use Committee of Sun Yat-sen University (Approval No

Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor