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Blood (2019) 134:4458

Overactivation, use during late-stage disease characterized by NAD + depletion, or lack of tissue specificity may result in adverse effects, including oxidative damage, energy imbalance, or cell death

doi: 10.1210/jc.2004-1532 18 GeorgiM.KristensenW

163 (5), e361e373

2 ) The inflammatory reaction in multicellular organisms consists of an ensemble of vascular, tissular, and humoral modifications in response to a threat to tissue integrity