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For example, punicalagin intervention significantly enriched short-chain fatty acid-producing bacteria such as Akkermansia muciniphila and Ruminiclostridium 9 in the intestines of high-fat diet mice (Gao et al., 2024), while also increasing the abundance of Lachnospiraceae NK4A136 and Bifidobacterium , which have bile acid metabolism functions (Liu et al., 2024)

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Xu X, Sun S, Liang L et al (2021) Role of the aryl hydrocarbon receptor and gut microbiota-derived metabolites indole-3-acetic acid in sulforaphane alleviates hepatic steatosis in mice

These findings highlight the role of glutathione in the preservation or promotion of this compound, likely through antioxidant mechanisms