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The following additional adverse reactions were reported by greater than 1% but not more than 5% of the Depakote ER-treated patients in controlled clinical trials: Body as a Whole: Back Pain, Flu Syndrome, Infection, Infection Fungal Cardiovascular System: Hypertension Digestive System: Constipation, Dry Mouth, Flatulence Hemic and Lymphatic System: Ecchymosis Metabolic and Nutritional Disorders Peripheral Edema Musculoskeletal System: Myalgia Nervous System: Abnormal Gait, Hypertonia, Tremor Respiratory System: Rhinitis Skin and Appendages: Pruritus, Rash Special Senses: Conjunctivitis Urogenital System: Urinary Tract Infection, Vaginitis Based on a placebo-controlled trial of adjunctive therapy for treatment of complex partial seizures, Depakote was generally well tolerated with most adverse reactions rated as mild to moderate in severity

Zhang J, Gold KA, Lin HY, Swisher SG , Xing Y, Lee JJ, Kim ES, William WN Jr

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Pharmacogenomics of GPCR drug targets

Skin and Appendages: Discoid Lupus Erythematosus, Erythema Nodosum, Furunculosis, Maculopapular Rash, Pruritus, Rash, Seborrhea, Sweating, Vesiculobullous Rash