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SNPs in DIO2 , which converts precursor thyroid hormone T 4 to its active form T 3 , were also related to genetic susceptibility to OA development

Because TG2 activity is highly associated with cellular redox status and alterations in the bidirectional flux of cellular thiol modulate TG2 activity, regulation of thiol flux in cells probably affects the TG2-mediated aggregation of the GST tag and its interaction with cellular proteins

in the trans isomer, the same groups are on opposite sides

AD patients are also more susceptible to SARS-CoV-2 infection, with AD being a risk factor for a poor prognosis of COVID-19 infection [120]

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