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When Histamine Symptoms Extend Beyond Food A low-histamine diet may reduce meal-triggered symptoms, but it cannot by itself determine whether the patient has undermethylation, copper overload, pyroluria, mast-cell activation or another biochemical pattern

The exact mechanisms behind oligodendrocyte degeneration are not fully understood, but may include mitochondrial disruption due to a cuprizone-induced copper deficit, ferroptosis (Jhelum, 2020), and endoplasmic reticulum stress responses

In conjunction with the low number of genes identified this makes interpretation of the role of these pathways less convincing (Fig

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The numbers of patients treated with and without AZT were 3,059 and 5,221, respectively