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During the study, the subjects were exposed to laboratory stress

Excess ROS production can increase NF-kB expression in immune cells, leading to excess secretion of pro-inflammatory cytokines, including TNF-a, IL-1, IL-6, IL-8, IFN-g, iNOS, COX-2 [50]

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We performed an immunofluorescence assay on immune cells isolated from young and aged individuals using an antibody for H2AX and a peptide nucleic acid (PNA) probe for FISH against telomeric repeats (Methods)