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Oxaliplatin-induced peripheral neuropathy and identification of unique severity groups in colorectal cancer

Koami H

Biochemistry (Mosc.) 32, 33683376

A recent study showed that metformin exerts its anti-senescence effect by targeting senescent mesenchymal stem cells (MSC) in CKD (Shavlakadze et al., 2018)

While the IC 50 of UNC10088 alone was 248 nM, the addition of FBXO22 reduced the IC 50 value by about 2.5-fold (IC 50 = 101 nM), indicating positive cooperative binding with an -factor of 3.3 (Fig