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However, ketamine began to be abused in the late 1970s and its side effects and potential for abuse have limited its wider and routine clinical use [108]

On this basis it appears urgent to organize an appropriate clinical trial in order to evaluate whether an initial cycle including at least 32 treatments during four months (twice weekly) can modify critical parameters including glycemic and C-reactive peptide levels, nonenzymatic glycosilation, aldose reductase activity, advaced glycated endproducts (AGEs) and the antioxidant-pro-oxidant balance

However, despite the limitations of this pilot study, the results suggest that further investigation is warranted

In total, 78 1 H-NMR spectra were analyzed

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