glutathione s-transferase mechanism The role of S-transferases in human disease pathogenesis and their current inhibitors Simplified scheme of action of

Stress-induced blood brain barrier disruption: molecular mechanisms and signaling pathways

In the brains of Alzheimers disease (AD) patients, pathological features such as reduced mitochondrial membrane potential (m), accumulation of mitochondrial peroxides, aberrant opening of the mitochondrial permeability transition pore (mPTP), and mitochondrial iron (mFe) overload are commonly observedeach closely linked to ferroptosis induction (Chen et al., 2023

NRF2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that drives the transcription of several genes involved in antioxidant protection such as those involved in glutathione synthesis (GCL and GS) and glutathione regeneration (GR) (20)

Some are caused by direct damage to organs, such as the lungs, and others are due to persistent inflammation and immune activation

Proteasome-bound UCH37/UCHL5 debranches ubiquitin chains to promote degradation