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TmSkzi, S., GyeNGe, L., PeLCder, ., AboNyi, T., & Lsztity, R

Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions

Dr Flaviano Giorgini, Reader in Neurogenetics of the Universitys Department of Genetics and senior author of the paper, said: We are taking advantage of genetic approaches in simple model organisms in order to better understand Huntingtons disease, with the aim of uncovering novel ways to treat this devastating disorder

doi: 10.1111/acel.13602

Taken together, these studies suggest that C-terminal truncated Syn variants may act as molecular decoy sequestering heterogeneous molecules, both proteins and membrane organelles, in their vicinity through nonfunctional interaction, leading to diffuse cellular aggregates or LB nucleation, as observed in various neurodegenerative disorders 83