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J Anim Sci 95:18131826

The antioxidant uric acid and depression: clinical evidence and biological hypotheses

Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans

By removing the PTEN gene from the oocytes of mouse primordial follicles, it is possible that the formation of primordial follicles and the early activation of the entire primordial follicle pool during puberty would be facilitated