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Figure 2 GRP78-specific antibodies were found in up to 63% of RA patients, 7% of patients with other rheumatoid diseases, and only 1% of healthy controls ( In vitro experiments revealed that in synovial cells, TNF and IL-1 increased GRP78 expression

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Recent evidence suggests that at moderately high concentrations, certain forms of ROS such as H2O2 may act as signal transduction messengers

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Temporal profile of serum metabolites and inflammation following closed head injury in rats is associated With HPA axis hyperactivity

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Similarly, iron dextran therapy resolved kidney macrophage iron depletion by suppling LIP and downregulating TfR1, which polarizes macrophages toward M1 for chronic kidney disease therapy [233]

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