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It is essential for: Mitochondrial energy production (ATP) DNA repair and cellular resilience Activation of sirtuins , proteins involved in metabolism and healthy aging Redox balance , helping cells respond to metabolic stress NAD levels naturally decline with age and may be lower in people with metabolic disease, chronic inflammation, or prolonged stress

Dual function of antioxidant activity Advanced-stage tumors are equipped with mechanisms of adaptation to increased levels of oxidative stress

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[DOI] [PubMed] [Google Scholar] 61.Kemp S, et al

It may prevent the binding of the FOXO4 protein with p53, allowing p53 to bind with DNA and trigger apoptosis in senescent cells