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The pharmacokinetic profile of maropitant when administered subcutaneously to cats at a dose of 1 mg per 1 kg of body weight is characterized by a maximum concentration (Cmax) in the blood plasma of about 165 ng/ml on average 19 minutes after administration (Tmax)

some research suggests it stays in circulation longer

When this process is blocked, Tramadol accumulates in the body, increasing the risk of serious neurological side effects

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(11) Although large doses may have side effects in some groups, generally doses up to 2,000 mcg/day are considered safe in case of deficiency