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49 Role of GH-IGF1 axis Obesity reduces the secretion of growth hormone (GH) and insulin-like growth factor-1 (IGF1) from the liver

This leads to the neutralization of their positive electrostatic charge, which may influence protein interactions with substrates, cofactors, and other macromolecules 116,117,118

Little JP, Forbes SC, Candow DG, Cornish SM, Chilibeck PD

This study, along with reference 150, identified a novel bypass mechanism that could render KRAS-addicted cancer cells resistant to RAS-targeted therapy