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The actual system consists of the full geometry of the molecule and is treated as MM layer while the model system consists of the chemically most important part of the system, (known as the core) of the system, which is treated as the QM layer

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We also explored the mechanisms of EV biogenesis, cargo selection, and their effects on recipient cells which may provide novel insights into CF pathogenesis and open new avenues for EV-based therapies aimed at improving disease management

PSEN2 variants may also increase -secretase activity and A42 production but are less common than PSEN1 variants and are associated with less aggressive disease progression (Xiao et al., 2021)

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