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Rather than relying on a single mechanism, these compounds act through multiple antioxidant pathways

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To support biochemical processes related to vitamin B12 in patients with vitamin B12 deficiency, cyanocobalamin is typically administered, followed by aquacobalamin, and even less frequently, the active forms in the human body, methylcobalamin or 5-adenosyl-5-cobalamin

Differential pathophysiological mechanisms between CHS and EHS While CHS and EHS share core pathogenic pathways (e.g., hyperthermia, inflammation, cell death), their mechanistic features differ significantly due to distinct patient demographics and triggers: Inflammatory kinetics EHS (predominant in young, active individuals) is characterized by rapid, exertion-amplified inflammatory responses

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