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These findings suggest that gut redox homeostasis is a key beneficiary of the restorative processes associated with sleep but that the gut may also actively mediate the systemic effects of sleep, including on longevity and aging (Vaccaro et al., 2020)

Clinical studies examining oxidative stress biomarkers in individuals with migraine have found that the number of monthly headache days was negatively correlated with serum concentrations of two antioxidant enzymes, catalase and superoxide dismutase, and total antioxidant capacity while being positively correlated with serum levels of glutathione peroxidase 1, nitric oxide, and malondialdehyde (3739)

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NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

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