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Clinicians thus eliminate differential diagnoses, and rely on subjective, unspecific, and disputed clinical diagnostic criteriaa process that often takes years with patients being misdiagnosed and receiving inappropriate and sometimes detrimental care

VEGF also plays an immunosuppressive role in the TME by accumulating Tregs and repolarizing tumor-associated macrophages (TAMs) to M2-like phenotypes 2,5

The area under the curve (AUC) for descriptive statistics and the two-way ANOVA test were used to calculate the significance between curves, and mean values of 8 wells of the same condition were used as reference points