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Futhermore, in HepG2 cells, GA treatment activated AMPK signaling and reduced mRNA expression of key transcription factors in fatty acid synthesis, including SREBP-1c, LXR, and ACC, as well as fatty acid transporter proteins such as CD36 and FATP2, which mitigated palmitic acid-induced lipid accumulation (Tanaka et al., 2020a)

Nano Today 32 , 100851 (2020)

It was discovered that ovaries overexpressing SIRT1 had fewer atretic follicles along with more primordial follicles 77

Second Messengers

ROS induce inflammation by increasing the production of pro-inflammatory cytokines, especially IL-1, IL-8, and TNF- (176, 177)