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After adding protein A/G agarose and antibody, the mixtures were incubated on rotator at 4 C overnight

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Table 2 presents the differentially expressed microRNAs in the adipose, liver, kidney, and PFC tissues across both genotypes

Current treatment strategies aim to improve insulin resistance via weight loss and exercise, improve insulin sensitivity by the use of insulin-sensitizing agents (for example, pioglitazone) and reduce oxidative stress by the use of antioxidants, such as vitamin E