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These advantageous actions of the tested agents were accounted to their antioxidant, anti-inflammatory and anti-apoptotic properties, along with their abilities to modulate HMGB1/RAGE/JAK-2/STAT-3, PI3K/AKT/CREB/BDNF/TrkB, AMPK/SIRT-1/m-TOR and PERK/CHOP/GRP78/Bcl-2 hubs, as main contributors in the underlying pathophysiological mechanisms in MSG-induced ADHD-like behaviors (Graphical abstract)

Gao Y, Kang K, Liu Y, Li N, Han Q, Liu H, Kong W, Zhang X, Huang R, Yang Z, Qi Z, Zheng J, Li M, Wang H, Li J, Liu R, Wang S, Zhang W, Zhao M, Yu K (2021) Mechanisms of renal-splenic axis involvement in acute kidney injury mediated by the 7nachr-nf-b signaling pathway

10.1039/d1na00697e 97 ZhengN.FuY.LiuX.ZhangZ.WangJ.MeiQ.et al (2022)

Once a person becomes infected, early diagnosis of necrotizing fasciitis is notoriously difficult, with one study showing its misdiagnosed 71% of the time, according to the Agency for Healthcare Research and Quality