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Dimethyl fumarate (DMF), an FDA-approved drug prescribed for the treatment of multiple sclerosis (56), activates NRF2 by disrupting its interaction with KEAP1 ( Figure 7A ), allowing NRF2 to translocate to the nucleus and become transcriptionally active (57)

Gut microbiota and metabolome distinctive features in Parkinson disease: Focus on levodopa and levodopa-carbidopa intrajejunal gel

Following an acute administration of EtOH (5 g/kg, i.p.), KO animals exhibited 30% and 50% less EtOH and AA accumulation in circulation, respectively, suggesting an increased capacity for liver EtOH and AA metabolism in KO mice

doi: 10.3390/nu14214622 139 BaranipourSAmini KadijaniAQujeqDShahrokhSHaghazaliMMirzaeiAet al

Specific delivery of therapeutic RNAs to cancer cells via the dimerization mechanism of phi29 motor pRNA