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To confirm whether selenomethionine can be converted into selenocysteine through the transsulfuration pathway to regulate the protein levels of GPX4, we detected the GPX4 of OS-RC-2, HepG2, and HT1080 cultured in medium with or without selenomethionine, cystine or RSL3

The cells were then incubated with different concentrations of hydrogen peroxide solution (H 2 O 2

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Research participants using Retatrutide at higher doses lost up to 24.2% of their body weight over 48 weeks

doi: 10.3389/fbioe.2025.1662900 Received 09 July 2025 Revised 17 August 2025 Accepted 22 August 2025 Published 19 November 2025 Volume 13 - 2025 Edited by Iman Yazdi, Moderna Therapeutics, United States Reviewed by Guoxu Zhao, Hainan University, China Ali Abba Mutah, Lehigh University, United States Updates Copyright 2025 Bi, Chen, Pang, Song, Li, Feng, Jiang, Zhang and Hu