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Chronic airway infection/inflammation induces a Ca 2+ i-dependent hyperinflammatory response in human cystic fibrosis airway epithelia

Although LDR-induced ROS in humans has not been that well-studied, individuals exposed to LDR (0.004 Gy/year) showed increased H 2 O 2 production and antioxidant expression, and their cells showed susceptibility to apoptosis (Russo et al., 2012)