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Nat Rev Nephrol 14(10):626635

L.ZhangC

3, 2016, p

Semaglutide continues to provide appetite suppression, metabolic benefits, and weight loss efficacy even after side effects have resolved, confirming that the mechanisms of benefit are distinct from the mechanisms of transient side effects

570,571 For example, based on the unique mechanism of action of ASOs, the main safety issues are severe hepatotoxicity and nephrotoxicity caused by drug accumulation