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Woods KA, van Helvoirt M, Ong KK, Mohn A, Levy J, de Zegher F, Dunger DB: The somatotropic axis in short children born small for gestational age: relation to insulin resistance

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As mentioned above, it is well documented across species that prolonged sleep deprivation increases susceptibility to oxidative stress in the form of increased mitochondrial ROS which in turn increases sleep pressure

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Although the mechanisms remain uncertain, it is hypothesized that the term HPA axis is more susceptible to glucocorticoid-mediated downregulation of central GR expression, leading to impaired negative feedback regulation