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It is ubiquitous in living systems

When tumor cells are detached from the ECM, glucose metabolism and mitochondrial respiration are inhibited, leading to reduced cellular energy synthesis and increased intracellular ROS levels, indicating the important role of ECM adhesion in cellular metabolism (125)

In previous studies that compared the differentiation capacity of chondrocytes from different passages, the results indicated that cells at early passages usually generated more cartilage matrix than those at late passages upon chondroinduction ( There are several limitations in the current study

While these treatments aren't snake oil, the scientific evidence is limited and the benefits may not be as dramatic as you'd hope