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KD and KB are capable to increase mitochondrial respiration via an increase in ATP production and improve the efficiency of the mitochondrial respiratory chain complex with increased mitochondrial biogenesis (107)

The combination therapy was able to reduce infarct volume, preserve BBB integrity, attenuate microglia activation, decrease the required tPA dose, and improve neurological outcomes, even better than tPA alone [215, 216]

Finally, viral proteins Nef and Vpr have also been shown to be associated with BBB permeability and neurotoxicity (Ferrucci et al

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On the basis of imaging studies using the FDG-PET method (2-[18F] fluoro-2-deoxy-D-glucose), reduced glucose metabolism in specific areas of the brain, such as the parietotemporal cortex and hippocampus, is detected years before the clinical symptoms of Alzheimers disease appear