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Across human studies and reviews, adverse effects are uncommon at typical supplemental intakes, and when side effects do occur, they are usually mild and gastrointestinal in nature.12 13 44 A safety-focused review published in European Review for Medical and Pharmacological Sciences summarized available clinical and non-clinical data on myo-inositol and reported that only very high intake (around 12g per day) was consistently associated with side effects specifically mild gastrointestinal symptoms such as nausea, gas/flatulence, and diarrhea.44 The authors also noted that the severity of these effects did not increase with higher doses

doi: 10.1002/ar.25562 40 LiJQiuS-JSheW-MWangF-PGaoHLiLet al

They are produced through a non-enzymatic glycation process called the Maillard reaction, which uses the carbonyl groups of reducing sugars and the free amino groups of proteins as substrates (Figure 2) (81)