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Wound healinga tightly coordinated cascade involving keratinocytes, macrophages, fibroblasts, and endothelial cellsrequires robust angiogenesis during the proliferative phase to establish a nutrient/oxygen supply via granulation tissue vascularization [12, 15]

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Discussion In this study, we demonstrated that activation of the FGF2 signaling pathway is a conserved mechanism for acquired resistance to anti-VEGF therapy in two mouse tumor models

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