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S15 and Supplementary Table S6) RMC liver metastases have increased transcriptional similarity to myeloid cells after treatment with nivolumab plus ipilimumab To measure whether tumor cells treated with ICT are undergoing cell state changes, we utilized the single-cell entropy (SCENT) 21 algorithm to quantify tumor cell entropy, a robust proxy for a cells differentiation potential

It is a component of glutathione 19

Similarly, the small molecule activator 2-APQC effectively enhances SIRT3 activity, alleviating cardiac hypertrophy and myocardial fibrosis induced by isoproterenol (ISO)