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Another assumption is that a malfunction of the hypothalamicpituitaryadrenal (HPA) axis, which also contributes to the pathophysiology of depression, leads to upregulation of vitamin D receptor expression in these areas and increased vitamin D activity due to the presence of the enzyme 1-alpha-hydroxylase

Neuroreport 19 , 987990 (2008)

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References Anderson WJ, da Cruz NFS, Lima LH, Emerson GG, Rodrigues EB, Melo GB

In vitro and in vivo neutralization of the relapsing fever agent Borrelia hermsii with serotype-specific immunoglobulin M antibodies