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Hepatocytes in Mat1a-/- mice showed a higher expression of cytochrome P450 family 2 subfamily E member 1 (CYP2E1) and a reduction in mitochondrial membrane potential (6264)

As a result, the heart struggles to circulate blood effectively, causing symptoms such as lethargy, coughing, and difficulty breathing

doi: 10.1038/ncomms8768

We also thoroughly discuss the recent advances made in the field and caveats that need to be overcome for clinical translation of cell therapies aimed at modulating non-cell autonomous events to preserve remaining motor neurons in patients