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Nrf2 is a potential modulator for orchestrating iron homeostasis and redox balance in cancer cells

In conclusion, the current study demonstrated, for the first time, that GSH depletion induces ferroptosis in RPE cells

Abbreviations ACE: Angiotensin I-converting enzyme ACSL4: AcylCoA synthetase longchain family member 4 AIF: Apoptosis-inducing factor Akt: Protein kinase B ALOX: Arachidonate lipoxygenase Apaf-1: Apoptotic protease activating factor-1 Bax: Bcl-2 associated X Bcl-2: B cell lymphoma 2 BDNF: Brain-derived neurotrophic factor BH4: Tetrahydrobiopterin CoQ10: Coenzyme Q10 COX: Cyclooxygenases CT: Chemotherapy CYP: Cyclophosphamide DHFR: Dihydrofolate reductase ERK: Extracellular signal-regulated kinase FSP1: Ferroptosis suppressor protein-1 FTH-1: Ferritin heavy chain-1 FTL-1: Ferritin light chain-1 GABA: Gamma-aminobutyric acid GPX-4: Glutathione peroxidase-4 GSK: Glycogen synthase kinase HO: Heme oxygenase IL: Interleukins iNOS: Inducible nitric oxide synthase IB: Kinase IKK JNK: Jun N-terminal kinase Keap1: Kelch-like ECH-associatedprotein 1 LncRNAs: LONG non-coding RNA LOX: Lipoxygenase MAPK: Mitogen-activated protein kinase mPTP: Mitochondrial permeability transition pore mTOR: Mammalian target of rapamycin NCOA4: Nuclear receptor coactivator 4 NF-B: Nuclear factor-kappa B NLRP: Nod-like receptor NOX: NADPH oxidase Nrf2: Nuclear factor-erythroid factor 2 PI3K: Phosphatidylinositol-3 kinase PLOOH: Phospholipid hydroxylperoxide PPAR-: Peroxisome proliferator-activated receptor- PUFA-CoA: Polyunsaturated fatty acid coenzyme-A PUFAs: Polyunsaturated fatty acids ROS/RNS: Reactive oxygen/reactive nitrogen species SIRS: Systemic inflammatory response syndrome SIRT1: Silent information regulator T1 SLC7A11: Light-chain subunit solute carrier family 7 member 11 SNP: Sodium nitroprusside STAT: Signal transducers and activators of transcription System Xc : Glutamate-cysteine transporter system TFR: Transferrin receptor TLR-4 : Toll-like receptor-4 TLR-4: Toll-like receptor-4 TNF: Tumour necrosis factor-alpha TRAIL: TNF-Related apoptosis-inducing ligand UPR: Unfolded protein response USP-14: Ubiquitin-specific protease-14 Wnt: Wingless-related integration site m: Mitochondrial membrane potential References Abdul-Hamid M, Salah M (2016) Intervention of ginger or propolis ameliorates methotrexate-induced ileum toxicity