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Animals were allocated to two dietary regimens: standard pellet diet or 60% Kcal HFD for 10 weeks

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Analysis of endpoint plasma electrolytes revealed that male and female DK rats became severely hypokalemic (Table 1) after 5 weeks of the diet, and the HK groups experienced elevated plasma K +

Recent studies have demonstrated that uncoupled NOS activity contributes to CRC progression by generating reactive oxygen/nitrogen species (ROS/RNS)

For example, the expression of ALOX15 is mediated by spermidine/spermine N1-acetyltransferase 1, a tumor protein p53 (TP53) target gene, and is involved in TP53-mediated ferroptosis (Ou et al., 2016)