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Unlike the NADPH-specific GR, MDHAR can use NADH or NADPH (Hossain et al

16 Paradoxically, while APR-246 clinical development is the most advanced in AML with TP53 mutation, the effects of APR-246 have been little studied in this disease

GPX4 converts glutathione (GSH) to oxidized glutathione (GSSG) and converts lipid peroxides to the corresponding alcohols, thus preventing the occurrence of Fenton reactions and subsequently inhibiting ROS generation (Liu Y

A limitation to global methylation analyses is that they can only detect major DNA methylation changes, ignoring local changes