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Description

Chronic metabolic stress induces beta cells to adopt a senescence-associated secretory phenotype (SASP), characterised by cytokines and ECM remodelling factors, that spreads into the surrounding environment promoting beta cell failure [57]

Hyperthyroidism (an overactive thyroid gland) can also cause these symptoms

Skeletal and cardiac muscle cell membranes exhibit greater resistance to PLA 2 , although both crude venom and melittin exert toxic effects on the cardiovascular system

Furthermore, our work confirmed previous observations that the reductive metabolism of TNBS by specific flavoproteins, eg, GSSG reductase, generates ROS, including hydrogen peroxide (Grisham et al, 1991)