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& Dawson, M

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This increase in Skp2-mediated Lkb1 ubiquitination, with a subsequent increase in FAO activity, was verified in vivo in Treg recovered from a dextran sodium sulfate-induced colitis murine model

doi: 10.1016/j.cell.2022.06.003 58 StrlicM.RadoviT.KolarJ.PihlarB

Such cross-contamination or additional stress to the sample may occur by applying too much pressure during tissue infiltration or due to microscope properties (strong light source, high temperature, lack of oxygen, water stress), but likewise during organelle isolation or fractionation (Zechmann 2014)