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Professor Ngs research contributions to AOD-9604 development include: Synthesis and characterization of the modified C-terminal growth hormone fragment with enhanced stability Design of the tyrosine N-terminal modification to improve peptide stability and half-life Preclinical studies demonstrating lipolytic effects in obese animal models Advancement of the peptide through multiple phases of clinical development Investigation of mechanisms underlying beta-3-adrenergic receptor modulation His work established the foundation for understanding peptide-based approaches to metabolic regulation, though clinical translation ultimately proved unsuccessful

Warfarin and other coumarin anticoagulants Weight loss and dietary changes can both affect INR (a measure of how quickly the blood clots) in people on warfarin

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Stratification of analyses provided more granularity to interpret findings, and sensitivity analyses were conducted to account for the use of ARVs associated with either weight loss or weight gain to isolate the potential role of DOR

2022 Nov;10(11):3876-89