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Papp K, Reich K, Leonardi CL, Kircik L, Chimenti S, Langley RG, Hu C, Stevens RM, Day RM, Gordon KB, Korman NJ, Griffiths CE (2015) Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1)

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A wealth of studies in non-depressed populations with medical conditions (including hypertension) have demonstrated the association between cardiovascular parameters and telomere length 90,92

In addition to the intrinsic compensation by Gstp3, exogenic compensation such as guidance cues and cell-cell interactions could help correct the defects, especially in orientation

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